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KMID : 1144820180240030183
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대한의생명과학회지
2018 Volume.24 No. 3 p.183 ~ p.195
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Comparison of Virulence between Five Strains of Cryptococcus Species Complex in a Rat Model
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Park Gyu-Nam
Kim Sun-Young
Kim Hye-Ran
Jung Bo-Kyoung
An Dong-Jun
Hong Seung-Bok
Chang Kyung-Soo
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Abstract
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Cryptococcosis, which is caused by the Cryptococcus species complex (including Cryptococcus neoformans and Cryptococcus gattii), is well known as one of the most important medical problems. However, the of the Cryptococcus species complex is still limited to pneumonia and meningitis. In particular, the differences in virulence among the five major serotypes of the Cryptococcus species complex are not fully understood. To elucidate the virulence of the Cryptococcus species complex when it is disseminated hematogenously, rats were infected by different strains of the Cryptococcus species serotype, and their histopathological characteristics were compared after infection. The cumulative mortality ratio of rats infected with serotype B strain was slightly higher than in the other experimental groups. In addition, the average recovery of the Cryptococcus species complex from rats infected with serotype B strain was significantly higher than in the other groups in almost all organ samples except spleen. The recovery of the Cryptococcus species complex was associated with the severity of histopathological lesions, including bleeding, inflammation, and tissue damage in all organs. In rats infected with serotype B strain, the virulence was the most severe, especially in the lungs and liver. These results indicate that the pathophysiology of the Cryptococcus species complex infection differs according to serotype.
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KEYWORD
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Cryptococcus species complex, Serotype, Virulence, Histopathological change, Rat model
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